E3 UBIQUITIN LIGASE MARCH5 POSITIVELY REGULATES JAPANESE ENCEPHALITIS VIRUS INFECTION BY CATALYZING THE K27-LINKED POLYUBIQUITINATION OF VIRAL E PROTEIN AND INHIBITING MAVS-MEDIATED TYPE I INTERFERON PRODUCTION

ABSTRACT Membrane-associated RING-CH-type finger (MARCH) proteins, a class of E3 ubiquitin ligases, have been reported to be involved in the infection of multiple viruses and the regulation of type I interferon (IFN) production.However, the specific role and mechanisms by which MARCH proteins influence Japanese encephalitis virus (JEV) infection re

Leading role in the process of development and improvement of modern Russian education plays an additional professional education, which, to the greatest extent, responds to the qualitative changes in the socio-economic relations in a rapidly changing world.The aim of this paper is to identify the organizational and legal problems of professional a

To diagnostics of Freight the evaporation of tumor tissue by radiation of single-mode medical CO2 laser is proposed a laser Doppler diagnostic method based on autodyne detection (reception on a laser resonator) of backscattered radiation from the evaporation zone.Intraoperative diagnostics of laser tissue evaporation lets surgeon to determine in re

Popliteal tendon tears without concomitant damage to the cruciate ligaments or other posterolateral corner ligaments are rare entities with few studies reporting on their existence, with rare Drying Glove case reports discussing their treatment.Continued pain, instability, and effusions are typical symptoms, with magnetic resonance imaging being th

Budgeting plays an important role on increasing efficiency of organizations.It helps determine targets and possible future chaos a head of time.A good budgeting plan can create motivation among workers and managers.There are different budgeting plans such as traditional and operational.In this paper, we analyze the effects of executing budgeting pl